Identification of fused pyrimidines as interleukin 17 secretion inhibitors
نویسندگان
چکیده
منابع مشابه
Diversity oriented syntheses of fused pyrimidines designed as potential antifolates.
Diversity oriented syntheses of some furo[2,3-d]pyrimidines and pyrrolo[2,3-d]pyrimidines related to folate, guanine, and diaminopyrimidine-containing drugs have been developed for the preparation of potential anti-infective and anticancer compounds. Amide couplings and Suzuki couplings on the basic heterocyclic templates were used, in the latter case yields being especially high using aromatic...
متن کاملSYNTHESIS OF 4,4'-BIS-PYRIMIDINES AND SOME RELATED BIS-FUSED PYRIMIDINES
2,2'-Disubstitutedamino-4-4'-bis-pyrimidines (3a-m) have been prepared by linking 2,4-dichloro-6-methyl-5-nitropyrimidine (1) with several diamines and subsequent reaction with suitable amines. Some of these compounds (3c and 3j) which were reduced catalitically, on treatment with nitrous acid, urea in pyridine, and boiling thionyl chloride gave the corresponding bistriazolopyrimidin (6), ...
متن کامل5-(l-Adamantyl)pyrimidines as Inhibitors of Folate Metabolism1
Seven pyrimidines with a lipophilic substituent at position 5 have been investigated with respect to inhibition of both dihydrofolate reductases of Sarcoma 180 and Escherichia coli and site of inhibitory action in mammalian cells in culture. Of the 7 pyrimidines, 5 were competitive inhibitors of both dihydrofolate reductases, 1 was noncompetitive, and 1 produced no effect. The Sarcoma 180 enzym...
متن کاملExpanding the scope of fused pyrimidines as kinase inhibitor scaffolds: synthesis and modification of pyrido[3,4-d]pyrimidines.
Fused pyrimidine cores are privileged kinase scaffolds, yet few examples of the 2-amino-pyrido[3,4-d]pyrimidine chemotype have been disclosed in the context of kinase inhibitor programs. Furthermore, no general synthetic route has been reported to access 2-amino-pyrido[3,4-d]pyrimidine derivatives. Here we report a versatile and efficient chemical approach to this class of molecules. Our strate...
متن کاملsynthesis of 4,4'-bis-pyrimidines and some related bis-fused pyrimidines
2,2'-disubstitutedamino-4-4'-bis-pyrimidines (3a-m) have been prepared by linking 2,4-dichloro-6-methyl-5-nitropyrimidine (1) with several diamines and subsequent reaction with suitable amines. some of these compounds (3c and 3j) which were reduced catalitically, on treatment with nitrous acid, urea in pyridine, and boiling thionyl chloride gave the corresponding bistriazolopyrimidin ...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2018
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2018.06.019